OSM-INDUCED CD44 CONTRIBUTES TO BREAST CANCER METASTATIC POTENTIAL THROUGH CELL DETACHMENT BUT NOT EPITHELIAL-MESENCHYMAL TRANSITION

OSM-induced CD44 contributes to breast cancer metastatic potential through cell detachment but not epithelial-mesenchymal transition

Hunter Covert,1 Liliana F Mellor,2,3 Cody L Wolf,1 Nicole Ankenbrandt,1 Jacqueline M Emathinger,2 Ken Tawara,1 Julie Thom Oxford,1,2 Cheryl L Jorcyk1,21Boise State University, Biomolecular Sciences Program, Boise, ID 83725, USA; 2Boise State University, Department of Biological Sciences, Boise, ID 83725, USA; 3Oncología Molecular, Centro Nac

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Sequence determinants of human-cell entry identified in ACE2-independent bat sarbecoviruses: A combined laboratory and computational network science approach

Summary: Background: The sarbecovirus subgenus of betacoronaviruses is widely distributed throughout bats and other mammals globally and includes human pathogens, SARS-CoV and SARS-CoV-2.The most studied sarbecoviruses use the host protein, ACE2, to infect cells.Curiously, the majority of sarbecoviruses identified to date do not use ACE2 and iphone

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